Digestive Diseases Research Institute (DDRI)

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Major global research collaboration adds new piece to the complex puzzle of oesophageal cancer.

New findings of a meta-analysis of the largest clinical trial studies on polypill in an international study, indicated " Polypill with Aspirin" combination therapy, halve the risk of major cardiovascular events, without serious complications of aspirin.

A new article examines recent cancer incidence trends in the Islamic Republic of Iran and presents predicted incidence rates and numbers of new cases for the entire country for the year 2025.

An analysis of the first wave of the epidemic in Iran in 8902 people suggests the overall proportion of people with SARS-CoV-2 antibodies in their blood - known as seroprevalence - may be higher than rates based on clinical cases alone, at around 17.1% seropositivity vs 0.6% based on modelling from previous studies, by end of April 2020.

At an important historical event , Carcinogenicity of Opium Consumption , the most prominent achievement of more than two decades of research efforts of Iranian scientists in the "Golestan Cohort Study " was confirmed by the International Agency for Research on Cancer of the World Health Organization (IARC / WHO) and it will be published in Volume 126 of the IARC Monographs.

The results of an unprecedented population-based study in the world, conducted by Iranian scientists, show that opium use not only has no effect on reducing death due to diabetes, but also increases the risk of premature death in diabetic patients by 30%.

A new study published today in the journal Environmental Health Perspectives provides strong evidence that household burning of biomass and kerosene fuels, especially using stoves without a chimney, increases the risk of developing several cancers of the digestive tract.

According to the results of a large and unprecedented international study, high Non-HDL/LDL that was responsible for an estimated 3.9 million worldwide deaths caused by IHD (Ischaemic Heart Disease) and stroke has changed dramatically, especially in the geographical location.

A new international prospective study of fifty thousand individuals, published in the Lancet Global Health, provides robust evidence indicating that regular use of opium is associated with higher risk of developing cancers in different organs of the respiratory, digestive, urinary, and central nervous systems.

Iranian scientists led by Professor Reza Malekzadeh In collaboration with Scientists from International agency for Research on cancer and a team of international researchers, have identified a method for early detection of bladder cancer up to 10 years before the onset of symptoms and clinical diagnosis in asymptomatic healthy individuals and presented the world with the first scientific evidence based on prospective, long-term study.

The historical study of “Polypill” conducted by Iranian researchers, led by professor Reza Malekzadeh – scientist of medical sciences in Iran – surpassed public attention in social media among all articles published by the “The Lancet” in 2019.

The researchers of the Digestive Diseases Research Institute of Tehran University of Medical Science, in a study proved for the first time in the world that Pharmacological prophylaxis of acute pancreatitis in ERCP alone is sufficient and does not require "pancreatic duct stenting with Pharmacological prophylaxis " in patients at risk.

Iranian researchers succeeded in producing PolyPill tablets to prevent myocardial infarction and strokes, and provided the strongest scientific evidence of the effect of this combination drug on significant reduction of cardiovascular diseases and myocardial infarction and strokes in the largest clinical trial of this kind in the world.

The meeting of 100 international scientists, including some researchers from Iran, seeking to understand the causes of cancer with new genetic approaches in collaboration with the major research project "MUTOGRAPHS", was held on July 11 and 12, 2019 at the International Agency for Cancer Research.

The head of the Digestive Diseases Research Institute of Tehran University of Medical Sciences announced the fatty liver the most common liver disease in Iran, and warned against an increase in its prevalence due to the worrying trend of immobility and obesity in the country

Obesity is increasing more rapidly in the world’s rural areas than in cities, according to a new study of global trends in body-mass index (BMI).

Iranian researchers in "Iran in Transition", the article which was published in the April 2019 in International Journal of The Lancet, have broadly examined the health status in Iran over the past centuries up to now.

Although statistics show that Iran has an estimated cases of 15,000 liver failure annually, and more than 5,000 Iranians die every year due to this disease, but Dr. Reza Malekzadeh, the deputy health minister of Iran, says that the country has been able to overcome all shortcomings and difficult obstacles, and by accomplishing more than 6,000 successful liver transplants, it has achieved stunning records in saving the lives of many of the people who die from this disease in 25 years of struggle.

The trend of hypertension with 39% increase in mortality due to it, has become a major threat in Iran during the past 25 years. Meanwhile, Dr Malekzadeh, Director of the Digestive Diseases Research Institute (DDRI) announced that 6.5 million Iranians have hypertension and are unaware of their disease.

With studies of researchers at the Digestive Diseases Research Institute of Tehran University of Medical Sciences, SOVODAK tablet (a combination of Sofosbuvir and Daclatasvir) was developed and the treatment of all genotypes of hepatitis C became definitive and easy

The Head of the Digestive Diseases Research Institute at Tehran University of Medical Sciences reported the annual incidence of more than 10,000 new cases of gastric cancer in the country, as well as the ranking of the 30 provinces for the rate of the deadliest cancer in Iran, as part of the first announcement for the results from the population-based "Gastric Cancer Registry” in Iran

The study of “Polypill” is one of the most important studies conducted at the Digestive Diseases Research Institute (DDRI), which resulted in the production of an effective drug for the prevention of heart attacks and brain strokes

Complete achievement of the goals in the Golestan Cohort Study prompted a new effort, which was the formation of a large, prospective, population-based study with the collaborative participation of medical universities on a population of 200,000 Iranian from all races and ethnicities, named the Persian Cohort Study. The key role of Iranian scientists for the realization of Precision Medicine in the next 20 years is one of its important objectives

The Golestan Cohort Study is the largest cohort study in the Middle East and North Africa, and part of the Gastroesophageal Malignancy in North of Iran (GEMINI) study, is one of the most important medical research projects in Iran.

The “hepatitis C” project is one of the most important research studies conducted by the Digestive Diseases Research Institute (DDRI) which resulted in an important achievement with regards to the definitive treatment of hepatitis C in the country and the survival of hundreds of patients.

The first official report of “Cancer Registry Based on the Entire Iranian Population", was accepted and approved for publication in “Cancer Incidence in Five Continents”, which is recognized as the most credible cancer reference by the WHO

The Islamic Republic of Iran became a permanent member of the INTERNATIONAL AGENCY FOR RESEARCH ON CANCER (IARC)