Given the prevalence and importance of duodenal ulcer disease and the important role of Helicobacter pylori in the onset of this disease, in the first five years of the GI diseases research center's activities affiliated to Digestive Diseases Research Institute, an important part of the research was devoted to this subject.
In these studies, the frequency (prevalence) of Helicobacter pylori was first found in these patients and the general population in some areas of the country, and it was shown that this microbe is found abundantly in our population, and its eradication not only has a very beneficial effect on the treatment of gastric and duodenal ulcers, but also significantly reduces the recurrence of this disease and prevents its major complications such as bleeding and intestinal obstruction, which make a lot of trouble for the patient, his/her family and the health system in the country.
One of the important studies in this field was the determination of Helicobacter pylori microbial susceptibility to drugs and antibiotics to determine the optimal treatment combination and duration in our country. Treatment regimens vary in different parts of the world and it is important to determine the appropriate treatment in each region.
 At present, research in this field is under way to develop microbiology knowledge about its biology and pathogenesis, as well as its frequency changes and its effects over time.

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