DR. Ahmadreza Niavarani

MD, PhD

Molecular Biologist

Biography:

•    Born: 1970, Tehran, Iran
•    Married, with two children

Experienced Assistant Professor with a demonstrated history of working in the higher education industry. Strong education professional with a Doctorate focused on Biotech from Pasteur Institute of Iran. Focused on molecular markers of leukemia while working as a post-doctoral fellow in Cancer Research UK. Interested in personalized cancer medicine, particularly in those areas involving endogenous mutagenic processes, including APOBEC/AID mutagenesis. Skilled in Genomics, Transcriptomics, and Bioinformatics.

Education:
•    MD: School of Medicine, Tehran University of Medical Sciences, Tehran, Iran, 1989-1996.
•    PhD: Pasteur Institute of Iran, Tehran, Iran, 1999-2005.
•    Postdoctoral Fellowship, Haematopoietic Stem Cell Lab, London Research Institute, Cancer Research UK, UK, 2008-2011.

Professional Experience:
•    Assistant Professor, Digestive Disease Research Institute, Tehran University of Medical Sciences, Iran, 2014-now.
•    Assistant Professor, Haematology-Oncology and Stem Cell Research Center, Tehran University of Medical Sciences, Iran, 2012-2014.
•    Postdoctoral Research Fellow, 2008-2011:
    o    Haematopoietic Stem Cell Lab, London Research Institute, Cancer Research UK, UK.
    o    Center of Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, UK.
•    Assistant Professor, Haematology-Oncology and Stem Cell Research Center, Tehran University of Medical Sciences, Iran, 2005-2007.
•    Post-graduate Student of Medical Biotechnology, Pasteur Institute of Iran, Tehran, 1999-2005.
•    General Practitioner, Tuyserkan, Hamedan, Iran, 1996-19
98.

Visiting Position:
•    Visiting Scientist, Mammalian Genetics Lab, London Research Institute, Cancer Research UK, UK, 2007-2008.
•    INSERM U636, Génétique du développement normal et pathologique, Nice, France, Mar-Nov. 20
03.

Honours and Awards:

•    1st Prize of 8th International Congress of Biochemistry & Molecular Biology, for “Analysis of Inheritance Pattern and Expression of BLG-shCT in Transgenic Mice”, Tehran, Iran, 2005.
•    Special prize of 7th Annual Festival on Student Book of the Year for translation of “Illustrated Harper Biochemistry”, Tehran, Iran, 2000.
•    Ranked 1st in Ph.D. Entrance Examination, Iran, 1999.
•    3rd prize of 4th Annual Festival on Student Book of the Year for translation of “Guyton’s Textbook of Medical Physiology”, Tehran, Iran, 1997.
•    Ranked 3rd in 4th National Comprehensive Basic Science Examination for medical students, Iran, 1991.

Technical Skills:
•    Molecular genetics: Core techniques, including DNA/RNA extraction, PCR, RT-PCR, quantitative RT-PCR, Next generation sequencing (NGS), siRNA and shRNA, RFLP, DNA cloning, Sanger sequencing, making DNA/cDNA libraries, Gene expression analysis, SNP analysis, capillary electrophoresis, Southern blotting, Western blotting.
•    Protein biochemistry: Immunoprecipitation (IP), gel filtration, gel electrophoresis, membrane dialysis, CsCl gradient separation, IMAC purification,ELISA.

•    Cell biology: Culture of different suspension and adherent cells, cell transfection and transduction, light and fluorescent microscopy, FACS analysis.
•    Transgenic animals: Different animal techniques, including mouse husbandry, embryo retrieval, micromanipulation, and genotyping.
•    Imaging: Radioisotope imaging, fluorescence imaging, chemiluminescence imaging.
•    Bioinformatics/Softwares: Integrative Genomics Viewer (IGV), GeneGo pathway analysis, Ingenuity Pathway Analysis (IPA), GenePattern suite, Gene-E, Gene Set Enrichment Analysis (GSEA), GeneSpring, Graphpad, Lasergene suite, SDS genotyping, CopyCaller, Haploview, Enhancer Element Locator (EEL), Primer Express, FlowJo, Entrez databases and tools, Syfpeithi, Cn3D.

Teaching Skills:
•    Gene Targeting: For PhD students of Tehran University of Medical Sciences, 2011-2013
•    Animal transgenesis: For PhD students of (a) Pasteur Institute of Iran and (b) Tehran University, 2003-2007.
•    Bioinformatics: For PhD students of (a) Tehran University and (b) Tehran University of Medical Sciences, and (c) different workshops held in Pasteur Institute of Iran, 2003-2007.
•    Principles of Mammalian Cell Culture: For MSc students of Hematology, Tehran University of Medical Sciences, 2006

Clinical Experience:
•    General practitioner from 1996 to 1998.
•    Co-designer and collaborator in study of tuberculin skin test in students of Tehran primary schools, 1995.
•    Co-designer and collaborator in study of nutritional status of Tehran people regarding ischemic heart disease risk factors, 1992.

Select Publications:
•    A Niavarani, AS Farahani, M Sharafkhah, and M Rassoulzadegan. Pancancer analysis identifies prognostic high-APOBEC1 expression level implicated in cancer in-frame insertions and deletions. Carcinogenesis. 2018 Mar 8;39(3):327-335.
•    A Niavarani, T Herold, Y Reyal, MC Sauerland, T Buchner, W Hiddemann, SK Bohlander, PJM Valk, and D Bonnet. A 4-Gene Expression Score Associated with High Levels of Wilms Tumor-1 (WT1) Expression Is an Adverse Prognostic Factor in Acute Myeloid Leukemia. British Journal of Haematology, 2016 Feb;172(3):401-11.
•    A Niavarani, S Horswell, R Sadri, and D Bonnet. The Wilms Tumor-1 (WT1) rs2234593 Variant Is an Independent Prognostic Factor in Normal-Karyotype Acute Myeloid Leukemia. Annals of Hematology, 2016 Jan;95(2):179-90.
•    A Niavarani, E Currie, Y Reyal, F Anjos-Afonso, S Horswell, E Griessinger, J Luis Sardina, D Bonnet. APOBEC3A is implicated in a novel class of G-to-A mRNA editing in WT1 transcripts. PLoS One. 2015 Mar 25;10(3):e0120089.
•    H Khanahmad, MR Noori Daloii, MA Shokrgozar, K Azadmanesh. A Niavarani, M Karimi, B Rabani, M Khalili, R Bagheri, F Maryami, S Zeinali, A novel single step double positive double negative selection strategy for beta globin gene replacement, Biochemical and biophysical research communications, epub 25 Apr 2006.
•    A Niavarani, S Dehghanizadeh, M Karimi, M Magliano, M Rassoulzadegan. Development of Transgenic Mice Expressing Calcitonin as a Beta-lactoglobulin Fusion Protein in Mammary Gland, Transgenic Research, Volume 14, Issue 5, Oct 2005, 719–727.

Translated Books

 •    Anatomy in Surgery, Trunk, 2nd edition, Thorek, 1985.
•    Cecil Essentials of Medicine, Cardiovascular System, 3rd edition, Andreoli, 1993.
•    Cecil Essentials of Medicine, Endocrine System, 4th edition, Andreoli, 1997.
•    Cecil Essentials of Medicine, Cardiovascular System, 4th edition, Andreoli, 1997.
•    Textbook of Medical Physiology, 9th edition, Guyton and Hall, 1996.
•    Textbook of Medical Physiology, 10th edition, Guyton and Hall, 2001.
•    Textbook of Medical Physiology, 11th edition, Guyton and Hall, 2006.
•    Textbook of Medical Physiology, 12th edition, Guyton and Hall 2011.
•    Textbook of Medical Physiology, 13th edition, Guyton and Hall 2016.
•    Pocket Companion to Textbook of Medical Physiology, 9th edition, Guyton and Hall, 1998.
•    Pocket Companion to Textbook of Medical Physiology, 10th edition, Guyton and Hall, 2001.
•    Pocket Companion to Textbook of Medical Physiology, 11th edition, Guyton and Hall, 2006.
•    Pocket Companion to Textbook of Medical Physiology, 12th edition, Guyton and Hall, 2011.
•    Pocket Companion to Textbook of Medical Physiology, 13th edition, Guyton and Hall, 2016.
•    Harper's Biochemistry, 25th edition, Murray et al., 2000.
•    Harper's Biochemistry, 26th edition, Murray et al., 2003.
•    Harper's Biochemistry, 27th edition, Murray et al., 2006.
•    Harper's Biochemistry, 28th edition, Murray et al., 2009.
•    Harper's Biochemistry, 29th edition, Murray et al., 2012.
•    Harper's Biochemistry, 30th edition, Murray et al., 2015.

Contact:

Address: North Kargar Ave, Shariati Hospital, Digestive Diseases Research Institute, Postal Code 14117-13135
Tel: +98 21 8241 5290
Fax: +98 21 8241 5400
Email: niavarani@tums.ac.ir

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